RES 211231 Exhibit A - Laserfiche WebLink

City of Pleasanton–10x Genomics Project Environmental Checklist and Initial Study/Mitigated Negative Declaration Environmental Evaluation FirstCarbon Solutions 41 Https://adecinnovations.sharepoint.com/sites/PublicationsSite/Shared Documents/Publications/Client (PN-JN)/2148/21480024/ISMND/wp/21480024 10x Genomics Project Full Screencheck ISMND.docx Table 7: Exposure Assumptions for Cancer Risk Receptor Type Exposure Frequency Age Sensitivity Factors (ASF) Fraction of time At Home (FAH) Daily Breathing Rate (DBR) 1 (L/kg-day) Hours/day Days/year Sensitive/Residential—Infant 3rd Trimester 24 350 10 1.00 361 0 to 1 year 24 350 10 1.00 1,090 1 to 2 years 24 350 10 1.00 1,090 Sensitive/Residential—Child 3 to 16 years 24 350 3 1.00 572 Sensitive/Residential—Adult > 16 years 24 350 1 0.73 261 Notes: (L/kg-day) = liters per kilogram body weight per day 1 The daily breathing rates recommended by the BAAQMD for sensitive/residential receptors assume the 95th percentile breathing rates for all individuals less than 2 years of age and 80th percentile breathing rates for all older individuals. Source: Bay Area Air Quality Management District (BAAQMD). 2016. Air Toxics NSR Program Health Risk Assessment (HRA) Guidelines. Website: http://www.baaqmd.gov /~/media/files/planning-and-research/rules-and- regs/workshops/2016/reg-2-5/hra-guidelines_clean_jan_2016-pdf.pdf?la=en. Estimation of Non-Cancer Chronic Hazards An evaluation of the potential non-cancer effects of chronic chemical exposures was also conducted. Adverse health effects are evaluated by comparing the annual receptor concentration of each chemical compound with the appropriate reference exposure limit. Available reference exposure limits promulgated by the OEHHA were considered in the assessment. Risk characterization for non-cancer health hazards from TACs is expressed as a hazard index. The Hazard Index is a ratio of the predicted concentration of the proposed project’s emissions to a concentration considered acceptable to public health professionals, termed the reference exposure limit. The hazard index assumes that chronic sub-threshold exposures adversely affect a specific organ or organ system (toxicological endpoint). For each discrete chemical exposure, target organs presented in regulatory guidance were used. To calculate the hazard index, each chemical concentration or dose is divided by the appropriate toxicity reference exposure level. For compounds affecting the same toxicological endpoint, this ratio is summed. Where the total equals or exceeds 1, a health hazard is presumed to exist. For purposes of this assessment, the TAC of concern is DPM for which the OEHHA has defined a reference exposure limit for DPM of 5 µg/m3. The principal toxicological endpoint assumed in this assessment was through inhalation. Estimation of Health Risks and Hazards from Project Construction To assess impacts to off-site sensitive receptors, receptor locations within the American Meteorological Society/Environmental Protection Agency Regulatory Model (AERMOD) model were placed at locations of existing residences, schools, and daycares located within approximately 1,000